Journal article
Clinical and molecular characterization of HER2 amplified-pancreatic cancer
A Chou, N Waddell, MJ Cowley, AJ Gill, DK Chang, AM Patch, K Nones, J Wu, M Pinese, AL Johns, DK Miller, KS Kassahn, AM Nagrial, H Wasan, D Goldstein, CW Toon, V Chin, L Chantrill, J Humphris, RS Mead Show all
Genome Medicine | Published : 2013
DOI: 10.1186/gm482
Abstract
Background: Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies. Methods: HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined HER2 amplification in a large cohort of patients (n = 469) with pancreatic ductal adenocarcinoma (PDAC). Results: An amplified inversion event (1 MB) was identif..
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Grants
Awarded by Royal College of Pathologists of Australasia
Funding Acknowledgements
The work was supported by the National Health and Medical Research Council of Australia (NHMRC; 631701, 535903, 535914); Cancer Council NSW (SRP06-01; ICGC09-01; SRP11-01); Australian Government: Department of Innovation, Industry, Science, Research and Tertiary Education (DIISRTE); Australian Cancer Research Foundation (ACRF); Queensland Government (NIRAP); University of Queensland; Cancer Institute NSW (06/ECF/1-24, 09/CDF/2-40, 07/CDF/1-03, 10/CRF/1-01, 08/RSA/1-15, 10/CDF/2-26,10/FRL/2-03, 06/RSA/1-05, 09/RIG/1-02, 10/TPG/1-04, 11/REG/1-10, 11/CDF/3-26); Garvan Institute of Medical Research; Avner Nahmani Pancreatic Cancer Foundation; R.T. Hall Trust; Jane Hemstritch in memory of Philip Hemstritch; Gastroenterological Society of Australia (GESA); Royal Australasian College of Surgeons (RACS); Sydney Catalyst Translational Cancer Centre; Royal Australasian College of Physicians (RACP); Royal College of Pathologists of Australasia (RCPA) and the St Vincent's Clinic Foundation.